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Lee and Yoo: Chemical colitis caused by hydrogen peroxide enema in a child: case report and literature review
This article has been retracted. See "Chemical colitis caused by hydrogen peroxide enema in a child: case report and literature review" in Volume 33 on page e2018005.


A 2-year-old girl, previously healthy, was brought to the emergency department because of significant cramping abdominal pain with recurrent hematochezia after an accidental hydrogen peroxide enema (35%, 5 mL) by her caregiver. She was hospitalized to the pediatric department and treated with nothing per mouth, intravenous fluid and parenteral antibiotic therapy. Laboratory, radiologic and endoscopic evaluation was performed during the admission period. She was discharged in a fully recovered state on the tenth hospital day, and this is the first case report of acute chemical colitis by accidental hydrogen peroxide enema in children.


Hydrogen peroxide is a chemical compound that has a single peroxide chain which is unstable and splits into reactive radicals. In the past it was used for therapeutic enemas to relieve meconium ileus in infants and fecal impaction in adults for nearly 100 years [1], but this practice has largely been abandoned after it was proven that it can cause colonic damage similar to that of ulcerative colitis or pseudomembranous colitis [1,2]. There are some case reports of chemical colitis resulting from self-administered hydrogen peroxide enema in naturopathic therapy in adults [2,3], but no case has been reported of caustic injury after ingesting hydrogen peroxide in children. We report a rare case of severe, acute colitis after administration of a hydrogen peroxide enema in a child.


A 2-year old girl was referred to our emergency department complaining of bloody stools and cramping abdominal pain for a 12-hour period. She was previously healthy and was taking no medication. Her caregiver reported rectally administering 5 mL of 35% hydrogen peroxide solution. They planned fecal disimpaction with glycerin suppositories for the defecation difficulty of their child. The hydrogen peroxide solution was stored in a home refrigerator for cleansing properties, but it was mistaken for a glycerin suppository. A small amount of hematochezia was noted.
On arrival at the emergency department, she was hemodynamically stable and in no respiratory distress. The abdominal physical examination revealed a soft abdomen with mild, diffuse tenderness and hyperactive bowel sounds. Rectal examination revealed non-specific findings. All results of blood tests were normal except for mild leukocytosis; white blood cell count was 10 900/μL and the hemoglobin (Hb) level was 11.4 g/dL. Her growth and development were normal and there was no evidence of physical or sexual child abuse.
Ultrasonography and plain abdominal film suggested a diffuse colonic distention (Figure 1). A flexible sigmoidoscopy was performed to assess the severity of the mucosal injury; it showed diffuse mucosal hemorrhage and marked edema with friability in the rectal mucosa (Figure 2). Pathologic findings revealed erosion of the surface and sloughing with lymphocyte aggregation (Figure 3). On subsequently obtaining a history, the caregivers indicated that the 35% hydrogen peroxide was used for natural health purposes. It was kept in a home refrigerator for cleansing properties, but it was mistaken for a glycerin suppository by them.
The patient was managed conservatively with nothing per mouth and antibiotics (metronidazole, 30 mg/kg/d). Hematochezia resolved within six hospital days and abdominal pain was improved on the third hospital day. The patient’s Hb level remained stable. The patient was hospitalized for 10 days and was discharged without complications.


Hydrogen peroxide is a clear, colorless, odorless oxidizing agent. It has concentrations ranging from 3% to 90%, and is widely available in a variety of medical and household products [4]. It is most often used as an irrigation and disinfecting solution, and 3% solutions are used as common household disinfectants. Therefore, it can be a common source of accidental poisonings, especially in children. Because of its instability and decomposability into water and oxygen in the presence of alkali or enzyme catalase, it can affect mucous membranes such as those in the liver, kidney, red blood cells and bone marrow. So, the quantity of oxygen produced exceeds maximum blood solubility; venous gas formation within the mesenteric and portal venous system can occur, resulting in systemic embolization and lipid peroxidation [5].
Chemical colitis is a type of colitis, an inflammation of the large intestine, caused by the introduction of chemicals to the colon by an enema or other procedures. Like other injury, the pathogenesis of hydrogen peroxide colitis is thought to be secondary to the chemical reaction resulting in penetration of highly reactive oxygen species, resulting in damage to the colonic mucosa [6,7]. The volume of oxygen liberated from the decomposition of hydrogen peroxide can be considerable, with 30 mL of 35% hydrogen peroxide yielding 3.5 L of oxygen, and it is thought to be secondary to absorption of hydrogen peroxide into the epithelial interstices and capillaries. So this rapid release of oxygen can lead to hollow viscous perforation. Hydrogen peroxide enteritis with 3% solution can cause instant bubbling on the mucosal surface followed by a whitening of the mucosa termed the ‘snow white’ sign [4]. After exposure, the colon becomes distended within moments. Despite the potential for severe injury from hydrogen peroxide, it has been used extensively throughout medical history [1]. In reported cases, many cases have occurred after accidental contamination of endoscopes with hydrogen peroxide in adults [8].
Clinical sequelae range from mild, self-limited colitis to strictures, perforations requiring surgery or even fatality [8]. For example, there is a report about a patient who developed chemical colitis with rectal bleeding after self-administration of a hydrogen peroxide enema in Korea, and the clinical course was good with conservative management [9]. But in another case report, the clinical presentation was consistent with acute ulcerative colitis symptoms – sudden onset of abdominal pain with bloody diarrhea – and the patient developed shock and died on the fourth hospital day [5].
Endoscopy should be performed in all hemodynamically stable patients to assess for injury because signs and symptoms do not consistently correlate with the extent of injury. The recommended treatments include bowel rest, broad spectrum antibiotics and fluid resuscitation [8].
In this case, the patient presented with symptoms that included abdominal pain and hematochezia. Clinical manifestations were similar to other cases of hydrogen peroxide enema in adults, and the radiologic and endoscopic findings were similar to other chemical colitis including mucosal friability and hemorrhage, but the ‘snow white’ sign was not seen. Pathologic findings were also similar to other cases of chemical colitis by hydrogen peroxide enema in adults [9]. Because this is the first report of chemical colitis caused by 35% hydrogen peroxide in children, we chose the recommended treatments for adults [8], and the clinical course was good in this child. However, she should be monitored for late-onset complications because there is no exact data about long-term complications of chemical colitis in children. Hydrogen peroxide is readily available from pharmacies in Korea, and several websites are available to the public that describe its use as an enema. Therefore, we believe clinicians and caregivers should be aware of this potentially lethal chemical culprit and pay attention to handling hydrogen peroxide because the storage and use of 35% hydrogen peroxide for natural health benefits can result in an emerging source for more a serious accident in children.

Conflict of interest

The authors have no conflicts of interest associated with the material presented in this paper.


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Figure 1.
An abdominal plain film on the day of the acute episode revealed diffuse gaseous dilatation of colonic loops (A) and small bowel gas pattern (B).
Figure 2.
A flexible sigmoidoscopy revealed diffuse mucosal hemorrhage (A and B), marked edema (C) with friability in the rectal mucosa (D) after rectal administration of 5 mL of 35% hydrogen peroxide.
Figure 3.
A photomicrograph of esophageal mucosal biopsy demonstrated surface erosion (A), lymphocyte aggregation (B and C) with sloughing (D)) in the sigmoid colon and rectal mucosa (H&E stain). H&F, hematoxylin and eosin.
Chemical colitis caused by hydrogen peroxide enema in a child: case report and literature review  2018 March;33(1)
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