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Journal of Environmental Toxicology 2010;25(2):145-151.
유수식 연속노출장비를 이용한 과불화화합물(PFOS, PFOA)이 송사리(Oryzias latipes) 알의 초기발생과정에 미치는 영향 연구
조재구, 김경태, 류태권, 박유리, 윤준헌, 이철우, 김현미, 최경희, 정기은
1국립환경과학원 환경건강위해성연구부 위해성평가과
2국립환경과학원 환경건강위해성연구부 위해성평가과
3국립환경과학원 환경건강위해성연구부 위해성평가과
4국립환경과학원 환경건강위해성연구부 위해성평가과
5국립환경과학원 환경건강위해성연구부 위해성평가과
6국립환경과학원 환경건강위해성연구부 위해성평가과
7국립환경과학원 연구전략기획실 미래전략연구팀
8국립환경과학원 환경건강위해성연구부 위해성평가과
9국립환경과학원 환경건강위해성연구부 위해성평가과
Toxicity of PFCs in Embryos of the Oryzias latipes Using Flow though Exposure System
Jae-Gu Cho , Kyung-Tae Kim , Tae-Kwon Ryu , Yuri Park , Junheon Yoon , Chul-woo Lee , Hyun-Mi Kim , Kyunghee Choi , Ki-Eun Jung
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ABSTRACT
  Perfluorinated chemicals (PFCs) is a kinds of persistent organic pollutants, and have the potential toxicity of which is causing great concern. In this study, we employed Oryzias latipes embryos to investigate the developmental toxicity of perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA)s compound using flow-throw system for 14 day. O. latipes embryos were exposed to solvent control, 20, 40 and 80 ㎎/L of PFOS and 62.5, 130,260 ㎎/L of PFOA respectively. After exposure, hatchability, mortality, total length and heart beats were examined. Hatching rates were reduced approximately 27% in the 80 ㎎/L PFOS-treated group and 17% in the 62.5, 130 ㎎/L PFOA-treated groups. Heart beats in the PFOS-treated groups were reduced at 7 day but, PFOA-treated groups were increased heart beats. 80 ㎎/L PFOS treated group showed significant reduction in growth (total length) level to 90% of control. But PFOA did not showed significant effect on growth. In the 14 days LC<SUB>50</SUB> of PFOS and PFOA was 22.74 ㎎/L and 173 ㎎/L, respectively. The overall results indicated that the early stage of O. latipes might be a reliable model for the testing of developmental toxicity to perfluorinated chemicals.
Keywords: Perfluorooctane sulfonate(PFOS); Perfluorooctanoic acid(PFOA); Oryzias latipes; Embryo developmental toxicity
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