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Journal of Environmental Toxicology 2010;25(2):121-129.
생쥐에서 황사로 인한 항원관련 천식성 기도 염증과 기도 과민성에 미치는 영향
임흥빈, 김승형
1충북대학교 농업생명환경대학 특용식물학과
2대전대학교 한의과대학 동서생명과학연구원
Effects of Allergen-related Asthmatic Airway Inflammation and Airway Hyperresponsiveness by Asian Sand Dust in Mice
Heung Bin Lim , Seung Hyung Kim
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ABSTRACT
  This study was carried out to investigate whether asian yellow sand dust (AS) has promoting effects of allergen-related airway inflammation and airway hyperresponsiveness, because the number of patient with allergic asthma and atopy, and with chronic bronchial inflammation and pneumonia have increased steadily in the cities of Korea. The appearance of AS collected was all round and nat, and the diameter was mostly below about 5 ㎛. When mice were treated with AS suspension by intratracheal instillation combined with ovalalbumin (OVA) sensitization chronically, the level of serum L-lactate dehydrogenase (LDH), IgE and histamine, and respiratory resistance was increased. Intratracheal instillation of AS and OVA also enhanced infiltration of eosinophils in the bronchoalveolar lavage fluid (BALF), IgE and eotaxin expression, and T helper type 2 cell derived cyrokines of interleukin (IL)-4, IL-13 and IL-5 as major contributors to allergy and asthma. These results indicate that AS elevates allergen-related airway inflammation and airway hyperresponsiveness in mice and may play an important role in the aggravation of respiratory diseases in Korea.
Keywords: Asian yellow sand dust; Airway inflammation; Eosinophil; Cytokine; Airway hyperresponsiveness
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