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Journal of Environmental Toxicology 2009;24(1):1-8.
금붕어 수정난의 2, 3, 7, 8-TCDD 노출에 따른 다이옥신 관련 유전자의 발현 및 형태학적 변화
오승민, 유병택, 김하룡, 정규혁
Early Life Stage Toxicity of 2, 3, 7, 8-Tetrachlorodibenzo-p-Dioxin(TCDD) in Goldfish(Carassius auratus)
Seung-Min Oh , Byung-Taek Ryu , Ha-Ryong Kim , Kyu-Hyuck Chung
ABSTRACT
  In this study, we obtained the fertilized eggs from goldfish (Carassius auratus) and observed normal developmental stage (from fertilized eggs to larvae) in non-exposed groups. Goldfish embryos at 3 h postfertilization (hpf) were statically exposed for 1 h to either dimethylsufoxide (DMSO, 0.1%. v/v) or TCDD (0.5 ㎍/L). Toxicity and morphological changes were characterized from 3 to 120 h postfertilization (hpf). Egg mortality (0~48 hpf) and hatching ratio (72~83 hpf) in TCDD-exposed group were significantly different from control groups. However, pericardial edema was first observed at 72 hpf, followed by the onset of yolk sac edema and mortality. In addition, goldfish embryos-larvae exposed to TCDD significantly increased TCDD-related gene such as CYP1A (24~72 hpf) and AhR2 (72 hpf). This is the first study about in-depth characterization of TCDD-induced developmental toxicity in goldfish (Carassius auratus).
Keywords: goldfish; TCDD developmental toxicity; early life stage; AhR; CYPIA
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