Effects of Carboxylethylgermanium Sesquioxide on the Cyclophosphamide-induced Immunotoxicity in Mice

, Oh-Hyun Jeong; , Ahn-Keun Kim; , Ki-Sook Yang; , Myoung-Yun Pyo

Published online January 1, 1986

Journal of Environmental Toxicology 2008;23(4):301-306.

마우스에서 carboxylethylgermanium sesquioxide가 cyclophosphamide로 유발된 면역독성에 미치는 영향

오현정, 김안근, 양기숙, 표명윤

Effects of Carboxylethylgermanium Sesquioxide on the Cyclophosphamide-induced Immunotoxicity in Mice

Oh-Hyun Jeong , Ahn-Keun Kim , Ki-Sook Yang , Myoung-Yun Pyo

ABSTRACT

To investigate the effects of carboxyethylgermanium sesquioxide (Ge-132) on the cyclophosphamide (CY)-induced immunotoxicity, hemagglutinin titer (HA-titer), splenic IgM plaque forming cells (PFC) and contact-delayed type hypersensitivity (CDTH) were assessed in mice. Ge-132 was orally administered alone (single dose of 300,600,900 ㎎/㎏ b.w.) or with CY (10 or 50 ㎎/㎏. i.p.) to mice on the 2nd day before. simultaneously with, the 2nd day after immunization. Within Ge-132 alone-treated groups, HA-titer and PFC to SRBC were significantly and dose-dependently enhanced when compared with control group. HA-titer and PFC numbers suppressed by the treatment of CY alone were significantly restored by the concomitant treatment of CY and Ge-132. Also, Ge-132 significantly decreased DNFB-induced CDTH and inhibited the CY-enhanced CDTH. These results indicate that Ge-132 may be able to increase humoral immunity and inhibit the immunotoxicity by CY.

Keywords: Ge-132; CY; HA-titer; PFC; CDTH