Tissue distribution of SiO₂ nanopaprticles was investigated in mice after oral administration or skin treatment. ICR Male mice were treated with SiO₂ nanoparticles 2,5 g/㎏/day for five consecutive days and sacrificed at 24 hours after the last administration. As results, the orally administered SiO₂ nanoparticels were distributed in the testis and kidney but not in lung at 24 hours after the last treatment. In case of skin treatment, SiO₂ nanoparticles were distributed to lung as well as testis, brain, kidney and liver. The results suggested that SiO₂ nanoparticles (12㎚) are easily absorbed through entero-gastric system or skin.
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