The tissue distribution of TiO₂, nanopaprticles was investigated in mice after oral administration, and skin treatment. Male mice were treated with the dose of 5 g/kg of TiO₂ for three consecutive days and sacrificed at 24 hours after the last administration. As results, the orally administered TiO₂ nanoparticels were shown to be distributed in the testis, lung, and brain at 24 hours after the last treatment. Kidney does not seem to be the main target of TiO₂ nanoparticle distribution. It means that TiO₂ nanoparticles (17 nm) are easily absorbed through entero-gastric system and may cause toxicity in brain, lung, and reproductive organs. The distribution of skin treatment showed the same pattern like oral administration.
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