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Journal of Environmental Toxicology 2007;22(3):219-225.
5-Oxohexyl-3, 7-dimethylxanthine이 사염화탄소로 유발된 흰쥐의 간손상에 미치는 영향
신혜순, 이보란
The Effect of 5-Oxohexyl-3,7-dimethylxanthine on Carbon Tretrachlroride-Induced Hepatotoxicity in Rats
Hea Soon Shin , Bo Ran Lee
ABSTRACT
  A series of new derivatives of 1-(5-oxohexyl)-3,7-dimethylxanthine has been prepared for the treatment of the vascular dementia. To investigate hepatoprotective effect of these derivatives, the serum biochemical activity and the histological change of liver tissue were evaluated in carbon tetrachloride (CCl₄) treated rats. The activities of aspartate aminotransferase and alanine aminotransferase and the activities of total cholesterol, triglyceride and total bilirubin in 5-oxohexyl-3,7-dimethylxanthine derivatives pretreated rats were signifi-cantly decreased compared to the CCl₄ only treated rats but the content of glutathione S-transferase was in-creased compared to the CCl₄ only treated rats. These results indicated that 5-oxohexyl-3,7-dimethylxanthine derivatives have hepatoprotective effect in CCl₄ intoxicated rats.
Keywords: hepatoprotective effect; 5-oxohexyl-3,7-dimethylxanthine derivatives; CCl₄
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