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Journal of Environmental Toxicology 2007;22(1):1-8.
생물학적 모니터링 데이터를 기초한 PBPK 모델의 활용
양미희, 양지연, 이빛나, 이호선
Application of Physiologically Based Pharmacokinetic Modeling with Biological Monitoring Data for Risk Assessment
Mihi Yang , Jiyeon Yang , Bitna Yi , Ho-Sun Lee
ABSTRACT
  Biological monitoring, analyses of internal dose for exposure to toxicants, has been thought as one of the best approaches for risk assessment. As the amount detected in human samples is generally very low, typically in the parts-per-bilion (ppb) or parts-per-trillion (ppt) range, analytic technologies such as HPLC, GC/MS, LC/MS, and LC/MS/MS have been continuously developed. In addition, route specific and sensitive exposure biomarkers have been developed for proper biological monitoring.
  PBPK modeling, particularly reverse dosimetry, has been emphasized as an useful method via interpretation of biological monitoring results for regulation of toxicants. Thus, this review is focused on the use of PBPK dosimetry models for toxicology research and risk assessment in Korea.
Keywords: PBPK; biological monitoring; risk assessment; biomarker; exposure
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