| Home | E-Submission | Sitemap | Contact Us |  
Journal of Environmental Toxicology 2007;22(1):1-8.
생물학적 모니터링 데이터를 기초한 PBPK 모델의 활용
양미희, 양지연, 이빛나, 이호선
Application of Physiologically Based Pharmacokinetic Modeling with Biological Monitoring Data for Risk Assessment
Mihi Yang , Jiyeon Yang , Bitna Yi , Ho-Sun Lee
  Biological monitoring, analyses of internal dose for exposure to toxicants, has been thought as one of the best approaches for risk assessment. As the amount detected in human samples is generally very low, typically in the parts-per-bilion (ppb) or parts-per-trillion (ppt) range, analytic technologies such as HPLC, GC/MS, LC/MS, and LC/MS/MS have been continuously developed. In addition, route specific and sensitive exposure biomarkers have been developed for proper biological monitoring.
  PBPK modeling, particularly reverse dosimetry, has been emphasized as an useful method via interpretation of biological monitoring results for regulation of toxicants. Thus, this review is focused on the use of PBPK dosimetry models for toxicology research and risk assessment in Korea.
Keywords: PBPK; biological monitoring; risk assessment; biomarker; exposure
PDF Links  PDF Links
Full text via DOI  Full text via DOI
Download Citation  Download Citation
CrossRef TDM  CrossRef TDM
Editorial Office
Division of Environmental Science and Ecological Engineering, Korea University
145 Anam-ro, Seongbuk-gu, Seoul 02841, Korea
Tel : +82-32-560-7520   E-mail: envitoxic@gmail.com
About |  Browse Articles |  Current Issue |  For Authors and Reviewers
Copyright © 2022 by The Korean Society of Environmental Health and Toxicology & Korea Society for Environmental Analysis.     Developed in M2PI