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Journal of Environmental Toxicology 2006;21(1):27-34.
한국인 채식 남성에서 비타민 D 수용체 유전자의 TaqⅠ 다형성의 분포 및 종골의 골밀도와의 관련성
강병용, 김소연, 이상진, 김현희
The Distribution of TaqI RFLP in the Vitamin D Receptor Gene in Korean Vegetarian Men and its Association with Calcaneal Bone Mineral Density
Byung Yong Kang , So Yeon Kim , Sang Jin Lee , Hyun Hee Kim
ABSTRACT
  Numerous studies reported the significant association between genetic polymorphisms in the vitamin D receptor (VDR) gene and various bone phenotypes such as bone mineral density (BMD) and bone quality, although conflicting results were produced. The objective of this study was to investigate the association between a TaqI RFLP in the VDR gene and calcaneal BMD in Korean vegetarian men, and its interaction with nutrition status as an environmental factor. BUA (broadband ultrasound attenuation), SOS (sound of speed) and stiffness index of the calcaneus were measured using an ultrasound bone densitometer in 266 Korean men (age: mean±SD; 50.9±12.0 year), and a TaqⅠ RFLP in the VDR gene analysed by PCR-RFLP method. In total subjects, the distribution of TT, Tt and tt genotypes occurred with frequencies of 90.8%, 8.8% and 0.4%, respectively. There were no significant associations between this polymorphism and osteopenia-osteoporosis or several bone phenotypes in our subjects irrespectively of nutrition status (P>0.05). Therefore, our results suggest that a TaqI RFLP in the vitamin D receptor gene does not contribute to the susceptibility to the calcaneal BMD in Korean men.
Keywords: calcaneus; vitamin D receptor; vegetarian
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