Combined Effect of Korean Red Ginseng and EGb 761 on Ultraviolet B-induced Contact Hypersensitivity

, Wookhee Choi; , Duksung Kim; , Hyoungsoo Ann; , Youngmi Lee; , Ryoungme Ahn

Published online January 1, 1986

Journal of Environmental Toxicology 2005;20(2):143-151.

UV-B 조사로 유도된 접촉 과민반응에 대한 홍삼과 홍삼+EGb 761 혼합물의 억제 효과 비교

최욱희, 김덕성, 안형수, 이영미, 안령미

Combined Effect of Korean Red Ginseng and EGb 761 on Ultraviolet B-induced Contact Hypersensitivity

Wookhee Choi , Duksung Kim , Hyoungsoo Ann , Youngmi Lee , Ryoungme Ahn

ABSTRACT

Exposure of skin to UV-B radiation can cause inflammatory response and immunosuppression. It has been reported that Korean Red Ginseng (KRG) has several pharmacological and physiological effects such as antioxidant, anticancer and improving immune function. In this study, we investigated that topical KRG and KRG±EGb 761 (Ginkgo biloba extract) combination prevented UV-B induced inflammation and inhibition of contact hypersensitivity response. Topical application of KRG, 5 days prior to or 5 days after exposure to 1MED and 2MED of UV-B, reduced skin thickness compared to non-treated group and resulted in protection against immunosuppression. However, KRG±EGb 761 combination has a little protection against the only 1MED UV-B. In conclusion. Topical application of KRG was more effective than combination in protection against UV-B induced inflammation and immune suppression. Also, we suggest that KRG can provide protection from inflammation and immunosuppression by UV-B radiation.