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Journal of Environmental Toxicology 2004;19(3):321-326.
다양한 환경변이원의 분자독성학적 메커니즘 연구에 있어서 항종양 인자 p53의 중요성 고찰
정화진, 류재천, 서영록
The Overview of the Importances of Tumor Suppressor p53 for Investigationg Molecular Toxicological Mechanisms of Various Environmental Mutagens
Hwa Jin Jung , Jae-Chun Ryu , Young Rok Seo
ABSTRACT
Thc study of p53 tumor suppressor protein is one of most important subjects in an environmental toxicology as well as in cancer biology Generally. p53 has been known to involve the cell cycle regulation and apoptosis by the activation of its target genes such as p21 and bax in a number of cellular stress responses In addition, associations of p53 with cellular proteins presumably reflect the involvement of p53 in critical cellular processes such as DNA repair The complex formation of p53 and exogenous proteins such as viral or cellular proteins has been shown in many cases to play important roles in careinogenic processes aganist environmental mutagen Recently the disruption of p53 protein by oxidative stress has been also reported to have relevance to carcinogenesis These findings suggested that the maintaining of stability and functional activity of p53 protein was also important aspect to play as a tumor suppressor protein Therefore, the detection of functional status of p53 proteins might be an effective biomarker for the cancer and human diseases under the environmental toxicologic carcinogen
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