Recently, waste plastic recycling technology is transforming from incineration system to pyrolysis gasification system which can derive the resources from environmental waste and charge no more environmental burden 10 nature. The present study was carried out 10 investigate the potential acute toxicity of derived product of pyrolysis gasification system for recycling of waste plastic by a single oral dose in Sprague-Dawley Rats. In order 10 evaluate the hepatotoxic effects of derived product of pyrolysis gasification system, activities of serum transaminase were measured in rats. No related changes in survivals, clinical signs and the ratio of the liver to body weights of rats were monitored. The results showed that the single oral administration of material of pyrolysis system for recycling of waste plastic did not induce any toxic effect at orally single dose level of 0 and 100, 200, 400, 800 mg/kg body weight in rats. We could not find out any significant tocxicity induced by single oral administrate of material of pyrolysis system for recycling of waste plastic.