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Journal of Environmental Toxicology 2003;18(4):255-269.
다매체/다경로 노출을 고려한 benzo(a)pyrene의 총 인체 노출량 예측
문지영, 양지연, 임영옥, 박성은, 신동천
Estimating Human Exposure to Benzo(a)pyrene through Multomedia/Multiroute Exposure Scenario
Ji Young Moon , Ji Yeon Yang , Young Wook Lim , Seong Eun Park , Ding Chun Shin
The objective of this study was to estimate human exposure to benzo(a)pyrene through multimedia/multi-pathway exposure scenario. The human exposure scenario for benzo(a)pyrene was consisted of 12 multiple exposure pathways, and the multipathway human exposure model based on this scenario constituted. In this study, the multipathway human exposure model was used to estimate the concentrations in the exposure contact media, human intake factors and lifetime average daily dose (LADDmodel) of benzo(a)pyrene in the environment. Sensitivity analysis was performed to identify the important parameters and Monte-Carlo simulation was undertaken to examine the uncertainty of the model. The total LADDmodel was estimated to be 5.52×10-7 mg/kg-day (2.06×10-7 ~8.65×10-7 mg/kg-day) using the multipathway human exposure model. The inhalation dose accounted for 78% of the total LADD, whereas ingestion and dermal contact intake accounted for 20.2% and 1.8% of the total exposure, respectively. Based on the sensitivity analysis, the most significant contributing input parameter was benzo(a)pyrene concentration of ambient air. Consequently, exposure via inhalation in outdoor/indoor air was the highest compared with the exposure via other medium/pathways.
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