Korean Journal of Environmental Toxicology 2002;17(2):161-174.
흰쥐에서 사염화 탄소로 유도된 간독성에 미치는 더위지기 추출물의 영향- I.사염화탄소 독성유발 심화 수준에 대한 더위지기 추출물의 회복효과
Effects of an Extract from A. gmelini Weber on Hepatotoxicity Induced by CCl₄ in Rats-I. Effects of an Extract from A. gmelini on Hepatotoxicity Induced by Different Levels of CCl₄
ABSTRACT
To investigate effects of A. gmelini on the 14-day CCl₄ induced hepatotoxicity, extracts were prepared in 3 ml saline at the dose of 5,000 mg/kg b.w. to administer orally once daily. Each concentration (5:5, 2.5:7.5, 1:9, CCl₄:olive oil v/v) of CCl₄ was orally administered with 2.5 ml/kg b.w., During the experiment, halves of the rats were sacrificed every 7 day and hemanalysis was done. On the 7th day, hemanalysis showed following recovery values; AST 52.6~61.4%, ALT 55.9~86.1%, ALP 46.0~70.9%, BUN 75.7~100.0<%, TBIL 55.2~96.1%, TCHO 38.0~63.7%, and TG 55.2~96.1%. On the 14th day, recovery values of each treatment were GOT 37.7~43.1%, GPT 19.8~45.9%, ALP 58.1~95.9%, BUN 57.6~100.0<%, TBIL 78.6~100.0<%, TCHO 56.9~100.0<%, and TG 10.0~51.2%. By histological examination of liver, hydropic degeneration, fatty change, lipid accumulation and necrosis were also recovered by administration of A. gmelini extract.
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