Environmental Analysis Health and Toxicology (EAHT)

Understanding the impact of Plant-Derived Food Grade Substances PDFGS on metal-induced neurodegeneration: A systematic review of preclinical evidence

Donatus Barido Dooka, Chidinma Promise Anyachor, Chinna Nneka Orish, Anthonet Ndidi Ezejiofor, Cecilia Nwadiuto Obasi, Chiara Frazzoli, Orish Ebere Orisakwe

Journal of Trace Elements and Minerals.2024; 7: 100110. CrossRef

The protective role of sesame oil against Parkinson's-like disease induced by manganese in rats

Wedad S. Sarawi, Hala A. Attia, Hatun A. Alomar, Rawan Alhaidar, Esraa Rihan, Nora Aldurgham, Rehab A. Ali

Behavioural Brain Research.2024; 465: 114969. CrossRef

Manganese Exposure Induces Cellular Aggregates and the Accumulation of β-Catenin in Skin of Zebrafish Embryos

Geyse Gomes, José Leonardo Oliveira, Manoel Luis Costa, Claudia Mermelstein, Natália Martins Feitosa

Signal Transduction Associated with Mn-induced Neurological Dysfunction

Xiao-wei Zheng, Yuan-yuan Fang, Jun-jie Lin, Jing-jing Luo, Shao-jun Li, Michael Aschner, Yue-ming Jiang

Biological Trace Element Research.2023;[Epub] CrossRef

Lipid headgroup and side chain architecture determine manganese-induced dose dependent membrane rigidification and liposome size increase

European Biophysics Journal.2022; 51(3): 205. CrossRef

Identification and Functional Analysis of LncRNAs in Response to Seed Aging in Metasequoia glyptostroboides by Third Generation Sequencing Technology

Yongjian Luo, Jingyu Le, Yixin Zhang, Ru Wang, Qing Li, Xinxiong Lu, Jun Liu, Zhijun Deng

Toxicity of heavy metals in plants and animals and their uptake by magnetic iron oxide nanoparticles

Ata Ur Rehman, Sadia Nazir, Rabia Irshad, Kamran Tahir, Khalil ur Rehman, Rafiq Ul Islam, Zahid Wahab

Journal of Molecular Liquids.2021; 321: 114455. CrossRef

Molecular Targets of Manganese-Induced Neurotoxicity: A Five-Year Update

Alexey A. Tinkov, Monica M. B. Paoliello, Aksana N. Mazilina, Anatoly V. Skalny, Airton C. Martins, Olga N. Voskresenskaya, Jan Aaseth, Abel Santamaria, Svetlana V. Notova, Aristides Tsatsakis, Eunsook Lee, Aaron B. Bowman, Michael Aschner

International Journal of Molecular Sciences.2021; 22(9): 4646. CrossRef

Post-Translational Modification of Cysteines: A Key Determinant of Endoplasmic Reticulum-Mitochondria Contacts (MERCs)

Calcium Ions Aggravate Alzheimer’s Disease Through the Aberrant Activation of Neuronal Networks, Leading to Synaptic and Cognitive Deficits

Frontiers in Molecular Neuroscience.2021;[Epub] CrossRef

Mn(II) complex of a vitamin B6 Schiff base as an exclusive apoptosis inducer in human MCF7 and HepG2 cancer cells: Synthesis, characterization, and biological studies

Zohreh S. Tabatabayi, Masoud Homayouni‐Tabrizi, Ali Neamati, S. Ali Beyramabadi

Journal of Cellular Biochemistry.2020; 121(3): 2677. CrossRef

Histopathological, genotoxic, and behavioral damages induced by manganese (II) in adult zebrafish

Gabriela Zimmermann Prado Rodrigues, Luciane Beatris Mentges Staudt, Marina Griebeler Moreira, Thainá Garbino dos Santos, Mateus Santos de Souza, Caio Júnior Lúcio, Jenifer Panizzon, Juliana Machado Kayser, Leonardo Airton Ressel Simões, Ana Luiza Ziulkos

Activation of protein kinase R in the manganese-induced apoptosis of PC12 cells

Kazuya Yagyu, Yuto Hasegawa, Mina Sato, Kentaro Oh-hashi, Yoko Hirata

Tetrahymena Glutathione Peroxidase Family: A Comparative Analysis of These Antioxidant Enzymes and Differential Gene Expression to Metals and Oxidizing Agents

Liliana L. Cubas-Gaona, Patricia de Francisco, Ana Martín-González, Juan Carlos Gutiérrez

Synthesis, X-ray Structure, Hirshfeld Analysis of Biologically Active Mn(II) Pincer Complexes Based on s-Triazine Ligands

Saied M. Soliman, Hessa H. Al-Rasheed, Ayman El-Faham

ZIP14 is degraded in response to manganese exposure

Effect of endoplasmic reticulum stress involved in manganese‑induced neurotoxicity in rats

Cailian Wu, Guandou Yuan, Ruikang Mo, Yanning Huang, Tiantian Luo, Jin Wang

17β-estradiol and tamoxifen protect mice from manganese-induced dopaminergic neurotoxicity

Edward Pajarillo, James Johnson, Judong Kim, Pratap Karki, Deok-Soo Son, Michael Aschner, Eunsook Lee

Neurotoxic Outcomes of Subchronic Manganese Chloride Exposure via Contaminated Water in Adult Male Rats and the Potential Benefits of Ebselen

Biological Trace Element Research.2018; 186(1): 208. CrossRef

Redox crosstalk at endoplasmic reticulum (ER) membrane contact sites (MCS) uses toxic waste to deliver messages

Hierarchical theranostic nanomedicine: MRI contrast agents as a physical vehicle anchor for high drug loading and triggered on-demand delivery

Guangqin Liu, Jian Deng, Fang Liu, Zheng Wang, Dan Peer, Yanjun Zhao

Journal of Materials Chemistry B.2018; 6(13): 1995. CrossRef

RETRACTED: Protective effect of exogenous hydrogen sulfide on pulmonary artery endothelial cells by suppressing endoplasmic reticulum stress in a rat model of chronic obstructive pulmonary disease

Hai-Bo Ding, Kai-Xiong Liu, Jie-Feng Huang, Da-Wen Wu, Jun-Ying Chen, Qing-Shi Chen

Biomedicine & Pharmacotherapy.2018; 105: 734. CrossRef

miR-125b regulates chemotaxis and survival of bone marrow derived granulocytes in vitro and in vivo

Chun-Wei Lee, Caroline Schoenherr, Karin Battmer, Arnold Ganser, Denise Hilfiker-Kleiner, Sascha David, Matthias Eder, Michaela Scherr, Shree Ram Singh

p73 gene in dopaminergic neurons is highly susceptible to manganese neurotoxicity

Dong-Suk Kim, Huajun Jin, Vellareddy Anantharam, Richard Gordon, Arthi Kanthasamy, Anumantha G. Kanthasamy

A 35 kDa Phyllanthus niruri protein suppresses indomethacin mediated hepatic impairments: Its role in Hsp70, HO-1, JNKs and Ca 2+ dependent inflammatory pathways

Sudip Bhattacharyya, Sharmistha Banerjee, Chirajyoti Guha, Shatadal Ghosh, Parames C. Sil

Food and Chemical Toxicology.2017; 102: 76. CrossRef

Redox dynamics of manganese as a mitochondrial life-death switch

Matthew Ryan Smith, Jolyn Fernandes, Young-Mi Go, Dean P. Jones

Biochemical and Biophysical Research Communication.2017; 482(3): 388. CrossRef

Polyphenolic Extract of Euphorbia supina Attenuates Manganese-Induced Neurotoxicity by Enhancing Antioxidant Activity through Regulation of ER Stress and ER Stress-Mediated Apoptosis

Entaz Bahar, Geum-Hwa Lee, Kashi Bhattarai, Hwa-Young Lee, Min-Kyung Choi, Harun-Or Rashid, Ji-Ye Kim, Han-Jung Chae, Hyonok Yoon

International Journal of Molecular Sciences.2017; 18(2): 300. CrossRef

The antagonistic effect of selenium on lead-induced apoptosis via mitochondrial dynamics pathway in the chicken kidney

Mitomycin C induces apoptosis in human epidural scar fibroblasts after surgical decompression for spinal cord injury

Tao Sui, Da-wei Ge, Lei Yang, Jian Tang, Xiao-jian Cao, Ying-bin Ge

Neural Regeneration Research.2017; 12(4): 644. CrossRef

Central nervous system manganese induced lesions and clinical consequences in patients with hereditary hemorrhagic telangiectasia

M. M. Serra, C. H. Besada, A. Cabana Cal, A. Saenz, C. V. Stefani, D. Bauso, A. B. Golimstok, J. C. Bandi, D. H. Giunta, C. M. Elizondo

Orphanet Journal of Rare Diseases.2017;[Epub] CrossRef

Levodopa (L-DOPA) attenuates endoplasmic reticulum stress response and cell death signaling through DRD2 in SH-SY5Y neuronal cells under α-synuclein-induced toxicity

Juhyun Song, Byeong C. Kim, Dai-Trang T. Nguyen, Manikandan Samidurai, Seong-Min Choi

Selenium protects against cadmium-induced kidney apoptosis in chickens by activating the PI3K/AKT/Bcl-2 signaling pathway

Environmental Science and Pollution Research.2017; 24(25): 20342. CrossRef

Quercetin Attenuates Manganese-Induced Neuroinflammation by Alleviating Oxidative Stress through Regulation of Apoptosis, iNOS/NF-κB and HO-1/Nrf2 Pathways

International Journal of Molecular Sciences.2017; 18(9): 1989. CrossRef

The protective effects of polysaccharide of Atractylodes macrocephala Koidz (PAMK) on the chicken spleen under heat stress via antagonizing apoptosis and restoring the immune function

Danning Xu, Bingxin Li, Nan Cao, Wanyan Li, Yunbo Tian, Yunmao Huang

9-Norbornyl-6-chloropurine (NCP) induces cell death through GSH depletion-associated ER stress and mitochondrial dysfunction

Pavla Plačková, Michal Šála, Markéta Šmídková, Milan Dejmek, Hubert Hřebabecký, Radim Nencka, Hendrik-Jan Thibaut, Johan Neyts, Helena Mertlíková-Kaiserová

Free Radical Biology and Medicine.2016; 97: 223. CrossRef

Role of ROS and RNS Sources in Physiological and Pathological Conditions

Sergio Di Meo, Tanea T. Reed, Paola Venditti, Victor Manuel Victor

Oxidative Medicine and Cellular Longevity.2016; 2016: 1. CrossRef

KHSRP Participates in Manganese-Induced Neurotoxicity in Rat Striatum and PC12 Cells

Shangshi Shi, Jianya Zhao, Lingling Yang, Xiaoke Nie, Jingling Han, Xia Ma, Chunhua Wan, Junkang Jiang

Journal of Molecular Neuroscience.2015; 55(2): 454. CrossRef

α-Synuclein Protects Against Manganese Neurotoxic Insult During the Early Stages of Exposure in a Dopaminergic Cell Model of Parkinson’s Disease

Dilshan S. Harischandra, Huajun Jin, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G. Kanthasamy

Toxicological Sciences.2015; 143(2): 454. CrossRef

ER stress and ER stress-mediated apoptosis are involved in manganese-induced neurotoxicity in the rat striatum in vivo

Ting Wang, Xuehui Li, Dongxu Yang, Hongtao Zhang, Peng Zhao, Juanling Fu, Biyun Yao, Zongcan Zhou

6-Shogaol induces cell cycle arrest and apoptosis in human hepatoma cells through pleiotropic mechanisms

Jung-Ju Wu, Hany A. Omar, Ying-Ray Lee, Yen-Ni Teng, Pin-Shern Chen, Yu-Chung Chen, Hsiao-Shan Huang, Kuan-Han Lee, Jui-Hsiang Hung

European Journal of Pharmacology.2015; 762: 449. CrossRef

A Comprehensive View of the Neurotoxicity Mechanisms of Cocaine and Ethanol

Renato B. Pereira, Paula B. Andrade, Patrícia Valentão

Neurotoxicity Research.2015; 28(3): 253. CrossRef

Alpha-Synuclein is Involved in Manganese-Induced ER Stress via PERK Signal Pathway in Organotypic Brain Slice Cultures

Bin Xu, Fei Wang, Sheng-Wen Wu, Yu Deng, Wei Liu, Shu Feng, Tian-Yao Yang, Zhao-Fa Xu

Molecular Neurobiology.2014; 49(1): 399. CrossRef

Minocycline Increases the Activity of Superoxide Dismutase and Reduces the Concentration of Nitric Oxide, Hydrogen Peroxide and Mitochondrial Malondialdehyde in Manganese Treated Drosophila melanogaster

Marylú Mora, Ernesto Bonilla, Shirley Medina-Leendertz, Yanauri Bravo, José Luis Arcaya

Neurochemical Research.2014; 39(7): 1270. CrossRef

Pivotal roles of p53 transcription-dependent and -independent pathways in manganese-induced mitochondrial dysfunction and neuronal apoptosis

Chunhua Wan, Xa Ma, Shangshi Shi, Jianya Zhao, Xiaoke Nie, Jingling Han, Jing Xiao, Xiaoke Wang, Shengyang Jiang, Junkang Jiang

Toxicology and Applied Pharmacology.2014; 281(3): 294. CrossRef

Toxicological & Environmental Chemistry.2014; 96(7): 981. CrossRef

Manganese accumulation in membrane fractions of primary astrocytes is associated with decreased γ-aminobutyric acid (GABA) uptake, and is exacerbated by oleic acid and palmitate

Environmental Toxicology and Pharmacology.2014; 37(3): 1148. CrossRef

Chikusetsu Saponin V Attenuates MPP+-Induced Neurotoxicity in SH-SY5Y Cells via Regulation of Sirt1/Mn-SOD and GRP78/Caspase-12 Pathways

Ding Yuan, Jing-Zhi Wan, Li-Li Deng, Chang-Cheng Zhang, Yao-Yan Dun, Yan-Wen Dai, Zhi-Yong Zhou, Chao-Qi Liu, Ting Wang

International Journal of Molecular Sciences.2014; 15(8): 13209. CrossRef

Iron depletion increases manganese uptake and potentiates apoptosis through ER stress

In VitroManganese Exposure Disrupts MAPK Signaling Pathways in Striatal and Hippocampal Slices from Immature Rats

Tanara Vieira Peres, Daniela Zótico Pedro, Fabiano Mendes de Cordova, Mark William Lopes, Filipe Marques Gonçalves, Cláudia Beatriz Nedel Mendes-de-Aguiar, Roger Walz, Marcelo Farina, Michael Aschner, Rodrigo Bainy Leal

BioMed Research International.2013; 2013: 1. CrossRef

Endoplasmic reticulum stress signaling involvement in manganese-induced nerve cell damage in organotypic brain slice cultures

Bin Xu, Ming Shan, Fei Wang, Yu Deng, Wei Liu, Shu Feng, Tian-Yao Yang, Zhao-Fa Xu

Minocycline forms complexes with manganese in vitro: Explaining reported beneficial effects in manganese treated Drosophila melanogaster

Anti-aging effects of deuterium depletion on Mn-induced toxicity in a C. elegans model

Daiana Silva Ávila, Gábor Somlyai, Ildikó Somlyai, Michael Aschner

An Involvement of Oxidative Stress in Endoplasmic Reticulum Stress and Its Associated Diseases

Bidur Bhandary, Anu Marahatta, Hyung-Ryong Kim, Han-Jung Chae

International Journal of Molecular Sciences.2012; 14(1): 434. CrossRef

The disruption of mitochondrial metabolism and ion homeostasis in chicken hearts exposed to manganese

Jing-Jun Shao, Hai-Dong Yao, Zi-Wei Zhang, Shu Li, Shi-Wen Xu